Former cop Brian O'Conner partners with ex-con Dom Toretto on the opposite side of the law. Since Brian and Mia Toretto broke Dom out of custody, they've blown across many borders to elude authorities. Now backed into a corner in Rio de Janeiro, they must pull one last job in order to gain their freedom. As they assemble their elite team of top racers, the unlikely allies know their only shot of getting out for good means confronting the corrupt businessman who wants them dead. But he's not the only one on their tail. Hard-nosed federal agent Luke Hobbs never misses his target. When he is assigned to track down Dom and Brian, he and his strike team launch an all-out assault to capture them. But as his men tear through Brazil, Hobbs learns he can't separate the good guys from the bad. Now, he must rely on his instincts to corner his prey... before someone else runs them down first.

Dominic Toretto and Brian O'Conner are still wanted men. They are now in Brzil along with Dom's sister, Mia. They were hired to do a job but it seems they were being used by someone and now that someone is after them. They decide to go after him so they bring in some of their friends to help them. And the same time, Luke Hobbs a government agent who specializes in tracking down fugitives arrives in Brazil and is determined to get them.

Former agent Brian O'Conner and his girlfriend Mia Toretto rescue her brother Dominic Toretto during transportation to prison, and they flee to Rio de Janeiro. They rob a car from custody and find that the powerful drug lord Hernan Reyes has US$ 100,000 in a safe located inside the police station, protected by corrupt policeman. Dominic invites his skilled crew to steal the dirty money and achieve their freedom, moving to a country without extradition to the USA. Meanwhile the tough FBI agent Luke Hobbs comes to Brazil with an elite force to arrest Dominic and Brian.